BBPUC 2025 – Cases
Below are links to the Virtual Pathology files for the 10 cases which will be discussed during the course.
Please review the cases which are hosted with our friends at Leeds Virtual Pathology, click on case image to open Virtual Pathology Page. You are then invited to use the Mentimeter link at bottom of page to submit the diagnoses. Full correct diagnoses and discussion will be given during the course by Dr Elena Provenzano, Dr Soha Elsheikh, Dr Clinton Boyd, Dr Bruce Tanchel and Professor Abeer Shaaban.
Dr Elena Provenzano
Chief Pathologist
Cambridge University Hospitals NHS Foundation Trust
1
History:
17 yo female. VAE B3 lesion
MCQ/Differential
1. Benign papilloma with epithelial displacement
2. Benign papilloma with LVI – cancer elsewhere
3. Encapsulated papillary carcinoma with LVI
Virtual Pathology Links
Please click on the image to have slide open up in the Leeds Virtual Pathology viewer
H&E
ER
CK14
D2-40
2
History:
81 yo female. PMH breast cancer and lymphoma. New masses right breast, core biopsy
MCQ/Differential
1. RecurrenT invasive lobular carcinoma
2. Breast involvement by lymphoma
3. Abscess with chronic inflammation
4. Metastatic melanoma
Virtual Pathology Links
Please click on the image to have slide open up in the Leeds Virtual Pathology viewer
H&E
MNF
Dr Soha El Sheikh
Honorary Associate Professor
University College London
3
History:
49 year old woman MRI: 72mm septated multiloculated mass centrally within the left breast, extending into all four quadrants, and from the nipple to the chest wall
MCQ/Differential
1. Fibrocystic change with LCIS
2. Cystic hypersecretory DCIS and LCIS
3. Atypical pregnancy like hyperplasia and LCIS
4. Serous- like breast carcinoma
5. Metastatic ovarian serous carcinoma
Virtual Pathology Links
Please click on the image to have slide open up in the Leeds Virtual Pathology viewer
H&E
H&E
CK5
P63
e-cadherin
4
History:
50 yr old woman with a cystic and solid lesion close to the nipple. Previous core biopsy – benign intraductal papilloma
MCQ/Differential
1. Papillary lesion with ADH
2. Benign papilloma and reactive adenosquamous proliferation
3. Adenosquamous carcinoma
4. Invasive NST carcinoma
5. Tubular carcinoma
Virtual Pathology Links
Please click on the image to have slide open up in the Leeds Virtual Pathology viewer
H&E
P63
SMM
CK5
Dr Clinton Boyd
Consultant Pathologist
Belfast Health and Social Care Trust
5
History:
Possible multifocal carcinoma left breast-papillary? Core biopsy of mass left upper outer quadrant
Please provide your Diagnosis
Virtual Pathology Links
Please click on the image to have slide open up in the Leeds Virtual Pathology viewer
H&E
ER
HER2
6
History:
Diffuse areas of thickening/hypoechoic change right lateral breast towards medial aspect in keeping with carcinoma. Core from right upper outer quadrant
Please provide your Diagnosis
Virtual Pathology Links
Please click on the image to have slide open up in the Leeds Virtual Pathology viewer
H&E
CK7
e-cadherin
ER
HER2
Dr Bruce Tanchel
Consultant Histopathologist
Heartlands Hospital, Birmingham
7
History:
48 year old female, core biopsy of left UOQ breast lesion
MCQ/Differential
1. Fibroadenoma with LCIS
2. Fibroadenoma with DCIS
3. Phyllodes tumour with LCIS
4. Phyllodes tumour with DCIS
Virtual Pathology Links
Please click on the image to have slide open up in the Leeds Virtual Pathology viewer
H&E
8
History:
82 year old female, core biopsy of right breast lesion
MCQ/Differential
1. Mucinous carcinoma
2. Micropapillary carcinoma
3. Metaplastic matrix producing carcinoma
4. Mucocele like lesion
Virtual Pathology Links
Please click on the image to have slide open up in the Leeds Virtual Pathology viewer
H&E
Professor Abeer Shaaban
Consultant Pathologist
Queen Elizabeth Hospital Birmingham
9
History:
Second opinion. 24 year old female. Left breast 4cm mass excision
MCQ/Differential
1. Fibroadenoma
2. Benign phyllodes tumour
3. Borderline phyllodes tumour
4. Malignant phyllodes tumour
5. Periductal stromal tumour
6. Adenomyoepithelioma
7. Tubular adenoma
Virtual Pathology Links
Please click on the image to have slide open up in the Leeds Virtual Pathology viewer
H&E
H&E
10
History:
Second opinion. 61 year old female, right breast WLE and SLNB. Section from breast lesion
MCQ/Differential
1. Lymphoma
2. Invasive NST carcinoma
3. Invasive lobular carcinoma
4. Metastatic carcinoma in a lymph node
5. Metastatic melanoma
Virtual Pathology Links
Please click on the image to have slide open up in the Leeds Virtual Pathology viewer
H&E
H&E
e-cadherin
